Cuenca, 17, joined the game in the 84th minute to replace Inigo Martinez, who had just found the back of the net in the dominating victory.
The teen has been on the bench for Barca this season, though without making the pitch until last night.
Cuenca is the latest youngster to be handed a chance this season by coach Hansi Flick, with fellow defenders Sergi Domínguez, Héctor Fort and Gerard Martín also all involved.