Rasmus Højlund and Christian Eriksen have been named in the starting lineup, which also means that Casemiro and Joshua Zirkzee will be starting the game on the bench.
So are Matthijs de Ligt and Lisandro Martinez. Harry Maguire and Jonny Evans start in central defence instead.
Man Utd XI: Onana; Mazraoui, Evans, Maguire, Dalot; Mainoo, Eriksen; Garnacho, Fernandes, Rashford; Hojlund.
Subs: Bayindir, Lindelöf, De Ligt, Martínez, Zirkzee, Diallo, Casemiro, Antony, Ugarte.
Aston Villa XI: Martinez; Cash, Konsa, Torres, Digne; Tielemans, Barkley; Philogene, Rogers, Bailey; Watkins.
Subs: Gauci, Carlos, Durán, Buendía, Nedeljkovic, Maatsen, Bogarde, Swinkels, Young.