Struijk sparked the comeback by scoring a header off a beautiful free-kick from fellow substitute Joe Rothwell in the 78th minute.
The same duo combined for the winner as another dangerous cross from Rothwell left the centre-back with an easy finish to head into an unguarded net with the final act of the game.
The winning goal sparked wild scenes of celebration among the capacity 38,000 crowd as one of English football's sleeping giants edge closer to a return to the top flight.
"These goals you celebrate differently," said Struijk.
"It's a big step in the season. We want to keep the distance with the ones that are chasing the same thing as us."
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Leeds move two points ahead of Sheffield United, but crucially seven clear of third-placed Burnley and 10 of Sunderland in fourth with 13 games remaining.
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(This story has not been edited by staff and is auto-generated from a syndicated feed.)